Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Dietary magnesium may reduce stones
Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018.
We wanted to understand the relationship between dietary magnesium intake and the prevalence of kidney stones. By examining data from the National Health and Nutrition Examination Survey spanning 2011 to 2018, we were able to analyze the self-reported history of kidney stones among participants.
Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.
In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.
While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
Read More
3
Magnesium affects urine, not stones
Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats.
We explored the effects of magnesium on kidney stones, focusing specifically on how it might influence urinary chemistry and calcium oxalate (CaOx) stone formation. Using genetic hypercalciuric stone-forming rats, we divided the animals into three groups, each receiving different levels of magnesium for six weeks.
After analyzing the 24-hour urine collection, we observed notable changes depending on magnesium intake. Those on a low magnesium diet had higher urinary supersaturation levels of CaOx, while the high magnesium group showed a significant decrease in urinary supersaturation. However, we need to stress that despite these changes in urine chemistry, magnesium did not impact the actual formation of calcium oxalate stones within the study period.
In summary, while increasing dietary magnesium can lower supersaturation in urine, it doesn't appear to prevent the formation of calcium oxalate stones in this rat model. This finding is important for understanding the role of magnesium in kidney stone prevention.
Read More
Most Useful Reviews
9
Strengthens bones safely
Very nice complex! It contains calcium and phosphorus hydroxyapatite, which is best absorbed and specifically strengthens teeth and bones, without being deposited in blood vessels or kidneys. For those needing calcium, this is a fantastic option!
Read More
9
No stones observed
Very good, no sediment, no stones.
Read More
7.5
Effective osteoporosis prevention
1 people found this helpful
This complex is very beneficial regarding the amount of calcium per tablet. I require one tablet a day, taking it for life. I support my 93-year-old mum with one tablet of this calcium and vitamin D for osteoporosis prevention. The calcium is in a readily absorbable form. The price is very reasonable. Magnesium oxide is ideal, ensuring the calcium goes where needed, rather than being deposited in blood vessels or kidneys. I drink vitamin D and will take K2 for life. I also include Omega-3, zinc chelate, lysine with monolaurin, and ascorbyl palmitate (vitamin C).
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Magnesium's complex role in kidney stones
Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles.
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.
Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.
On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.
Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.
Read More
8
Magnesium's role in kidney stones
Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study.
We analyzed a study focused on the effects of a combination of probiotics, potassium, and magnesium on kidney stone formation, specifically looking at crystalluria, which is the presence of crystals in urine that can signal the recurrence of kidney stones. The study involved 23 patients with calcium oxalate kidney stones who had crystalluria but normal metabolic profiles.
Over the course of 20 days, the patients received daily supplementation with beneficial bacteria, including Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium breve, along with potassium citrate and magnesium. After treatment, we observed a decrease in the presence of crystalluria at multiple follow-up points—1, 3, 6, and 12 months later.
Interestingly, while we noted that the probiotics and other agents helped reduce crystalluria, the study did not isolate the specific effects of magnesium alone. Therefore, we must be cautious in drawing firm conclusions about magnesium’s standalone effectiveness in this context.
Overall, the findings suggest that combining these supplements can be beneficial for patients with kidney stones, but the role of magnesium specifically requires further investigation.
Read More
8
Magnesium improves urine levels
Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria.
We aimed to find out how magnesium affects urinary levels of magnesium and citrate in people who form kidney stones and have low magnesium in their urine. By examining medical records, we compared two approaches: one group increased their magnesium through foods, while the other group received magnesium supplements.
We focused on adult patients whose urine magnesium levels were less than 70 mg a day. Following our recommendations, we observed significant changes after both dietary increases and supplementation. Those who took magnesium supplements showed a more pronounced improvement—about 88% were able to raise their urine magnesium to at least 70 mg a day, compared to just 58% in the dietary group.
Interestingly, only the supplement group showed a noticeable increase in urine citrate levels, which is also crucial in the prevention of kidney stones. Overall, both dietary and supplemental magnesium effectively improved magnesium levels, but supplementation had greater success in achieving desirable levels.
Read More
8
Dietary magnesium may reduce stones
Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018.
We wanted to understand the relationship between dietary magnesium intake and the prevalence of kidney stones. By examining data from the National Health and Nutrition Examination Survey spanning 2011 to 2018, we were able to analyze the self-reported history of kidney stones among participants.
Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.
In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.
While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
Very nice complex! It contains calcium and phosphorus hydroxyapatite, which is best absorbed and specifically strengthens teeth and bones, without being deposited in blood vessels or kidneys. For those needing calcium, this is a fantastic option!
Read More
9
No stones observed
Very good, no sediment, no stones.
Read More
7.5
Effective osteoporosis prevention
1 people found this helpful
This complex is very beneficial regarding the amount of calcium per tablet. I require one tablet a day, taking it for life. I support my 93-year-old mum with one tablet of this calcium and vitamin D for osteoporosis prevention. The calcium is in a readily absorbable form. The price is very reasonable. Magnesium oxide is ideal, ensuring the calcium goes where needed, rather than being deposited in blood vessels or kidneys. I drink vitamin D and will take K2 for life. I also include Omega-3, zinc chelate, lysine with monolaurin, and ascorbyl palmitate (vitamin C).
Read More
Frequently Asked Questions
Kidney stones are hard deposits made of minerals and salts that form inside your kidneys. While they can vary in size from tiny particles to large stones, they all begin as crystallized substances that develop when urine contains more crystal-forming substances than the fluid in your urine can dilute. When the crystals stick together, they can form stones, which may cause severe pain, especially when they pass through the urinary tract. Common types of kidney stones include calcium stones, struvite stones, uric acid stones, and cystine stones.
The symptoms of kidney stones can include sharp pain in the side and back, pain during urination, pink or red urine, and frequent urination. Various factors can increase the risk of developing kidney stones, including dehydration, certain dietary choices, and genetic predisposition. Preventing kidney stones often involves drinking plenty of water, avoiding excessive salt and animal protein, and ensuring a balanced intake of calcium. For those who suffer from kidney stones, a medical evaluation may be necessary to determine the best management and preventive strategies.
Calcium magnesium refers to a dietary supplement that combines two essential minerals, calcium and magnesium, which play critical roles in maintaining various bodily functions. Calcium is vital for building and maintaining strong bones and teeth, while magnesium supports muscle function, energy production, and the regulation of calcium levels in the body. Together, these minerals work synergistically to promote overall health, particularly in areas such as bone density, cardiovascular health, and muscle function.
Supplements that contain both calcium and magnesium can be particularly beneficial for individuals who may be deficient in these minerals due to dietary restrictions or health conditions. They are available in various forms, including tablets, capsules, and powders. When considering a calcium magnesium supplement, it's essential to choose a product with the right ratio of these minerals, as well as other supporting vitamins and minerals like vitamin D, which enhances calcium absorption. Always consult with a healthcare provider before starting any new supplement regimen to ensure it aligns with your health needs and goals.
Calcium and magnesium are minerals that play essential roles in various bodily functions, including bone health and muscle function. When it comes to kidney stones, research indicates that calcium may have a somewhat complex relationship. In fact, lower dietary calcium intake can increase the risk of developing calcium oxalate stones, the most common type of kidney stones. Therefore, maintaining an adequate calcium intake through diet can be beneficial, as it may help prevent stone formation by binding to oxalates in the gut and reducing their absorption.
Magnesium, on the other hand, has been shown to have potential protective effects against kidney stone formation. Some studies suggest that magnesium may inhibit the crystallization process of calcium oxalate stones and promote their breakdown. This can be particularly advantageous for individuals who are prone to recurrent kidney stones. However, it's important to consult with a healthcare professional for personalized advice, especially if you have a history of kidney stones or underlying health conditions. They can provide tailored recommendations regarding dietary supplements and lifestyle adjustments that may help in managing your kidney health.
The effectiveness of calcium magnesium supplements for preventing kidney stones can vary widely among individuals. While some users may begin to notice improvements in their symptoms or a reduction in stone formation within a few weeks, it may take several months for others to see significant results. The timeline can depend on various factors including the individual's diet, hydration levels, and the underlying cause of their kidney stones.
It's essential to note that while calcium can be beneficial in preventing certain types of stones, it is crucial to consult with a healthcare provider for personalized advice and monitoring. They can provide insights tailored to your specific situation, which can lead to a more accurate timeframe for when you might begin to notice the effects of the supplement. Additionally, lifestyle changes and dietary modifications often play a critical role in managing kidney stones and may impact your results as well.
The role of magnesium in preventing kidney stones is a mixed bag, with recent research presenting both protective and potentially harmful associations. For instance, a study found that higher dietary magnesium intake may correlate with lower odds of developing kidney stones, particularly in older adults [4]. Conversely, another analysis indicated that elevated urinary magnesium levels were associated with an increased risk of kidney stones, raising questions about its complex interplay with other minerals like calcium and phosphorus [3].
Moreover, some studies highlighted magnesium's potential benefits as a supplement, particularly magnesium citrate, for reducing oxalate levels in urine, which is crucial since high oxalate is a known risk factor for kidney stones [6]. However, it’s essential to draw cautious conclusions from these findings, as some research did not isolate the effects of magnesium alone [5]. Overall, while magnesium may have some role in modulating kidney stone risk, further investigation is needed to clarify its efficacy as a preventive supplement and understand the mechanisms at play.
Based on user reviews, several individuals have reported noticeable improvements in their health, particularly regarding bone strength and calcium absorption. One user highlights that the complex contains calcium and phosphorus hydroxyapatite, which they found to be ideally absorbed and effective in strengthening teeth and bones without adverse effects, such as deposits in blood vessels or kidneys. They praised it as an excellent option for those requiring calcium Read Review.
Another reviewer mentioned that taking a single tablet daily had significantly benefited their elderly mother, who requires calcium for osteoporosis prevention, suggesting that the formulation is not only effective but also convenient Read Review. Overall, users seem to appreciate the formula's focus on absorbability and the absence of sediment or stones, indicating a smoother supplementation experience Read Review. However, it's important to keep in mind that individual results can vary.
Based on user reviews, many individuals have found that combining this supplement with other supplements can enhance their management of kidney stones. One reviewer specifically mentioned taking this calcium and vitamin D complex alongside magnesium oxide, which they noted is ideal for ensuring that calcium is utilized effectively in the body rather than deposited in undesirable locations like blood vessels or kidneys Read Review. This combination suggests a thoughtful approach to supplementation, potentially reducing the risk of kidney stones while aiding in calcium absorption.
Moreover, users have praised the absence of sediment or stones when using this supplement, endorsing it as a safe option for those concerned about kidney health Read Review. While individual experiences may vary, the feedback indicates that this complex, when paired with the right additional supplements, could promote a healthy balance in calcium metabolism and support overall kidney function.
Users have reported positive experiences with Calcium Magnesium supplements concerning their potential role in treating or preventing kidney stones. Reviewers emphasize the importance of the right formulation and dosage, noting that the combination of calcium and magnesium aids in absorption and minimizes the risk of deposition in blood vessels or kidneys. One user specified the effectiveness of their preferred complex in preventing sediment and stones, declaring, "Very good, no sediment, no stones" Read Review.
Additionally, another user highlighted their routine, stating they take one tablet daily for long-term health, which they find beneficial in supporting both their needs and those of their elderly mother. This ongoing regimen points to a consensus on the practicality of a daily dose to support bodily functions without adverse effects Read Review. Overall, users advocate for the careful selection of calcium and magnesium forms, particularly those that promote absorption while reducing the risk of complications like kidney stones.
9
Strengthens bones safely
Very nice complex! It contains calcium and phosphorus hydroxyapatite, which is best absorbed and specifically strengthens teeth and bones, without being deposited in blood vessels or kidneys. For those needing calcium, this is a fantastic option!
7.5
Effective osteoporosis prevention
1 people found this helpful
This complex is very beneficial regarding the amount of calcium per tablet. I require one tablet a day, taking it for life. I support my 93-year-old mum with one tablet of this calcium and vitamin D for osteoporosis prevention. The calcium is in a readily absorbable form. The price is very reasonable. Magnesium oxide is ideal, ensuring the calcium goes where needed, rather than being deposited in blood vessels or kidneys. I drink vitamin D and will take K2 for life. I also include Omega-3, zinc chelate, lysine with monolaurin, and ascorbyl palmitate (vitamin C).
9
No stones observed
Very good, no sediment, no stones.
7
Magnesium reduces kidney stone risk
Association Between Magnesium Intake and Chronic Kidney Diseases and Kidney Stones in Adults Aged 50 years and Older: Dose-Response Analysis of a Nationally Representative Population-Based Study.
We examined the relationship between magnesium intake and the risk of kidney stones in adults aged 50 and older. By analyzing data collected from the National Health and Nutrition Examination Survey spanning over a decade, we aimed to understand whether increasing magnesium levels could help reduce the chances of developing kidney stones.
Our findings revealed that there is indeed a noteworthy link between magnesium consumption and kidney stones. Specifically, we observed that individuals who consumed higher amounts of magnesium had lower odds of experiencing kidney stones. This trend was especially significant for women, who showed a clearer inverse relationship with magnesium intake.
Interestingly, our results indicated that the protective benefits of magnesium plateau around a daily intake of 350 mg. This means that while increasing magnesium consumption can lower the risk of kidney stones, beyond this threshold, additional magnesium may not yield further benefits.
Overall, our study sheds light on the potential role of magnesium in preventing kidney stones and emphasizes the importance of maintaining a balanced diet rich in this essential mineral for individuals over 50.
8
Magnesium's complex role in kidney stones
Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles.
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.
Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.
On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.
Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.
9
Magnesium reduces kidney stone risk
Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
8
Magnesium's role in kidney stones
Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study.
We analyzed a study focused on the effects of a combination of probiotics, potassium, and magnesium on kidney stone formation, specifically looking at crystalluria, which is the presence of crystals in urine that can signal the recurrence of kidney stones. The study involved 23 patients with calcium oxalate kidney stones who had crystalluria but normal metabolic profiles.
Over the course of 20 days, the patients received daily supplementation with beneficial bacteria, including Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium breve, along with potassium citrate and magnesium. After treatment, we observed a decrease in the presence of crystalluria at multiple follow-up points—1, 3, 6, and 12 months later.
Interestingly, while we noted that the probiotics and other agents helped reduce crystalluria, the study did not isolate the specific effects of magnesium alone. Therefore, we must be cautious in drawing firm conclusions about magnesium’s standalone effectiveness in this context.
Overall, the findings suggest that combining these supplements can be beneficial for patients with kidney stones, but the role of magnesium specifically requires further investigation.
References
Ran Y, Liu Z, Ma H, Li C, Zhou J, et al. Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies. Medicine (Baltimore). 2025;104:e41323. doi:10.1097/MD.0000000000041323
Zhang J, Luo H, Wu H, Qian Y, Tang Z, et al. The association between domestic water hardness and kidney stone disease: a prospective cohort study from the UK Biobank. Int J Surg. 2025;111:1957. doi:10.1097/JS9.0000000000002198
Ma L, Qiao Y, Wang R, Chen H, Liu G, et al. Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles. Metabolites. 2024;14. doi:10.3390/metabo14120674
Zhao H, Wang Y, Guan L, Sun Y. Association Between Magnesium Intake and Chronic Kidney Diseases and Kidney Stones in Adults Aged 50 years and Older: Dose-Response Analysis of a Nationally Representative Population-Based Study. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.11.004
Vittori M, Bove P, Signoretti M, Cipriani C, Gasparoli C, et al. Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study. Urologia. 2024;91:681. doi:10.1177/03915603241272146
Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, et al. Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Magnes Res. 2024;37:12. doi:10.1684/mrh.2024.0524
Penniston KL, Coughlin MM, Jhagroo RA. Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.06.002
Li Q, Krieger NS, Yang L, Asplin J, Bushinsky DA. Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats. Nephron. 2024;148:480. doi:10.1159/000534495
Shringi S, Raker CA, Tang J. Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018. R I Med J (2013). 2023;106:20.
Rodriguez-Hesles CA, Alkhatatbeh H, Alonso Bartolomé MB, Valladares Ferreiro CA, Ayllón Blanco HR, et al. Urine alkalinization for dissolution of uric acid stones and treatment of other urological diseases with a treatment combining potassium magnesium citrate and theobromine. Arch Ital Urol Androl. 2025;97:13824. doi:10.4081/aiua.2025.13824